Australian study finds babies born using fertility treatment proneto serious defects

PARIS — Children conceived with the aid of fertility treatmentsare more likely to be born with serious physical defects, accordingan Australian study published Saturday. Conception using treatments like ovulation induction, in-vitrofertilization or the injection of sperm directly into an egg,resulted in serious defects in 8.3 percent of cases studied, theresearch team said. The corresponding ratio in spontaneous conceptions was 5.8 percent a very significant difference, lead researcher MichaelDavies told AFP of the University of Adelaide study published inthe New England Journal of Medicine. Something that is not often talked about in the clinic, Isuspect, is the risk of having an abnormal baby. And so thisemphasizes this is something that must be talked about betweenpatients and clinicians. Smart Car Turbocharger

They must discuss the risk for this when choosing thetreatment. Davies, from the university’s Robinson Institute for fertility,said the research had focused on serious defects, things thateither require treatment or if there is no treatment they are goingto be considered handicapping, like a heart condition or cerebralpalsy. The study covered 308,974 births registered in South Australiabetween January 1986 and December 2002, of which 6,163 had resultedfrom assisted conception. I don’t think there is any reason it wouldn’t be applicable tothe majority of clinics around the world, said Davies, callingfor further research. More than 3.7 million babies are born every year as a result offertility treatment. Isuzu Turbo Kits Manufacturer

The survey, which researchers said was the most comprehensive ofits kind yet, found that not all treatments were equally risky. The scientists noted birth defects in 7.2 percent of children bornfrom in-vitro fertilization (IVF) and 9.9 percent fromintracytoplasmic sperm injection (ICSI). For IVF, the percentage dropped significantly when taking intoconsideration factors like parental age, smoking and other factors,but for ICSI it remained high. ICSI, in which a sperm cell is injected directly into an egg, is aform of IVF which involves the fertilization of an egg outsidethe body, in a laboratory. Perkins Turbo Diesel

Davies said there were several theories on why ICSI was more risky possibly involving the use of damaged sperm or damage caused bymanipulation of the sperm and egg in the lab. With IVF, the sperm entered the egg of its own accord. There are factors associated with ICSI that require furtherresearch, he said. The researchers also found a tripling of risk in women usingclomiphene citrate, a drug for ovulation induction.

While confined to a small group in our study, this is ofparticular concern as clomiphene citrate is now very widelyavailable at low cost, said Davies.


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